Analysis and quantitation of a metabolite of doxycycline in mice rats and humans by HPLC
Summary
Type: HPLC Application #: 103770
Catalog#: 720022.40 - MN HPLC Column, Nucleosil C8, 100A, 10um, 4x250mm
Detection: UV, A) and B) 344nm, C) and D) 370nm Conditions: eluent: 3.5mmol/l aqueous NaH2PO4 - acetonitrile (70:30), pH 2.7 flow rate 1.9ml/min Authors: Böcker R H Source: J Chromatogr 274 (1983) 255 - 262
Details
Legend: Fig. 1. Chromatographic analysis of doxycycline and its metabolite, A) liver
extract of a control mouse, 6h after intravenous application of 50µg/g
doxycycline, B) liver extract of a phenobarbital p